In a recent study published online in JAMA Network Open on January 2, the utilization of cryopreserved oocytes has shown a notable increase among patients experiencing poor ovarian response (POR). The study, conducted by Yuval Fouks, M.D., M.P.H., from Boston IVF-The Eugin Group in Waltham, Massachusetts, delves into the relationship between ovarian response, the quantity of vitrified oocytes, and the likelihood and timing of patients returning for oocyte usage after planned oocyte cryopreservation.
The cohort study analyzed 67,893 autologous oocyte freezing cycles conducted in the United States between 2014 and 2020, involving 47,363 patients. Among these, 13.5 percent were categorized as patients with POR, having fewer than five oocytes vitrified across all ovarian stimulation cycles. A total of 2.5 percent of patients returned for oocyte warming and utilization. The study revealed a significantly higher return rate in the POR group compared to the normal responder group (4.0 versus 2.3 percent). This trend was more prominent in patients aged 30 to 34 years (16.7 versus 8.4 percent for warm cycle versus no warm cycle) and ages 35 to 39 years (21.1 versus 14.9 percent).
Notably, patients with POR and normal responders exhibited a similar duration from vitrification to warming. The multivariable analysis indicated that having fewer than five oocytes vitrified was linked to increased odds of utilizing oocytes, with an odds ratio of 1.52.
The authors emphasize the importance of comprehensive counseling, ensuring that patients are well-informed about the distinct utilization patterns across different ovarian response groups. Armed with this knowledge, individuals can make decisions aligned with their reproductive goals and prospective scenarios.
As cryopreservation technology continues to advance, the study sheds light on its growing relevance for patients facing challenges related to poor ovarian response, providing them with alternative pathways to fulfill their reproductive aspirations.
